I realise that I never provided an answer for this!!!michael_churchill wrote: ↑03 Aug 2022, 16:31 Which TV character's first wife was played by Emma Thompson in one series and by Laurie Metcalf in another series?
It's Frasier Crane.
Lilith was Frasier's second wife. At college, he was briefly married to Nanette Guzman who then became a well-known children's entertainment as "Nanny G". In one episode of 'Cheers' she was played by Emma Thompson, then in the final series of 'Frasier' she was played by Laurie Metcalf.